Enlightening inhibitory neurotransmitter receptor organization and dynamics applying high end microscopy (B05)

• Subject Area: Cell Biology ; Biochemistry ; Biological and Biomimetic Chemistry ; Biophysics ; Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2015 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 258780946

GABAA and glycine receptors are the major mediators of fast synaptic inhibition in the central nervous system and the brain, and thereby, critical for cognition, behavior, and consciousness. Here, we will systematically and comprehensively study the molecular mechanisms that control the numbers and the organization of these receptors at neuronal synapses. Receptor-protein interactions will be explored in vitro, functionally characterized in cells and in tissue material and visualized with high-end microscopy in unpreceded resolution. Thereby, our study shall help to decipher the specific (patho)physiological action of the most important receptor-associated proteins.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 166: High-end light microscopy elucidates membrane receptor function - ReceptorLight
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Heads: Professor Dr. Rainer Heintzmann, until 6/2019; Dr. Hans Michael Maric; Professorin Dr. Britta Qualmann