From regulation of alternative translation initiation to other aspects of post-transcriptional gene regulation: functional analyses of Sex-lethal and related proteins (B11)

• Subject Area: Biochemistry
• Term: from 2015 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 185476941

The Drosophila RNA-binding protein Sex-lethal (Sxl) is the master regulator of female development in somatic tissues. Numerous regulatory mechanisms operate to tightly control its sex- specific expression and to restrict its activity to female animals. Our aim is to understand in more detail how Sxl expression is regulated and how Sxl and related proteins exert their post-transcriptional regulatory activity on a molecular level.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 960: Ribosome Formation: Principles of RNP Biogenesis and Control of their Function
• Applicant Institution: Universität Regensburg
• Project Head: Privatdozent Dr. Jan Medenbach