Long noncoding RNAs in tissue homeostasis and disease (B09)

• Subject Area: General Genetics and Functional Genome Biology
• Term: from 2015 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 185476941

The project proposed here is designed to analyze the functional impact and modes of action of long non-coding RNAs (lncRNAs) and associated proteins on regulation of epidermal homeostasis in normal and neoplastic tissue. Objective 1: Characterization of the interaction between lncRNA LINC00941 and epigenetic regulator complexes. Objective 2: Analysis of modes of action of LINC00941, SPRR5 and associated proteins in regulation of epidermal differentiation gene clusters. Objective 3: Analyzing functional roles and modes of action of LINC00941, SPRR5 and associated proteins in human tissue neoplasia.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 960: Ribosome Formation: Principles of RNP Biogenesis and Control of their Function
• Applicant Institution: Universität Regensburg
• Project Head: Dr. Markus Kretz