Energy-metabolic interference as novel experimentaltherapeutic intervention for pathological forms of pain
(A07)
Subject Area
Molecular Biology and Physiology of Neurons and Glial Cells
Human Genetics
Clinical Neurology; Neurosurgery and Neuroradiology
Term
since 2015
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 255156212
In the previous funding period, we determined that spinal energy metabolism ––more specifically spinal astrocytic glycogen dynamics that we found to be triggered by inflammatory pain–– promotes spinal plasticity to aggravate pain hypersensitivity and pain maintenance. In the last funding period, we aim to further probe the metabolic pathways that fuel pain-induced plasticity in the spinal cord. We expect that we will not only gain detailed insight into the metabolic changes that occur in the spinal cord during noxious stimulation but also how astrocytic-neuronal metabolic coupling and metabolite flux effects pain behaviour in mice and whether energy-metabolic pathways can be harnessed for analgesic therapy.
DFG Programme
Collaborative Research Centres
