Longitudinal analysis of structural and functional changes in peripheral circuits determining the clinical symptoms of painful neuropathies (A03)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells ; Anatomy and Physiology ; Human Genetics ; Clinical Neurology; Neurosurgery and Neuroradiology
• Term: since 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 255156212

Structural and functional changes of the dorsal root ganglia and peripheral nerves that are associated with neuropathic pain have been shown to occur in disorders of the peripheral and the central nervous system. Project A03 uses magnetic resonance neurography to investigate the development of such changes and to objectively assess the impact of different therapeutic interventions on structure and function of the peripheral nervous system in neuropathic pain related to different diseases. For the recruitment of participants and for the interpretation of results in the clinical and pathophysiological context, Project A03 is closely linked to other projects in this collaborative research center.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1158: From nociception to chronic pain: Structure-function properties of neural pathways and their reorganisation
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Professor Dr. Martin Bendszus, since 7/2019; Dr. Vijayan Gangadharan, until 6/2019; Privatdozent Dr. Johann Jende, from 7/2023 until 3/2024; Professor Dr. Peter Nawroth, until 6/2023; Professor Dr. Mirko Pham, until 6/2019