Silent nociceptors in mice and humans (human-rodent tandem) (A01)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 255156212

Silent nociceptors significantly contribute to the development and maintenance of chronic pain by their sensitization leading to ongoing pain, primary hyperalgesia, and central sensitization. Project A01 investigates, both in mice and in humans, the molecular mechanisms that underlie the sensitization of silent afferents, and uses electrophysiological and viral approaches as treatment options. In patients predictive parameters that indicate successful local therapy are investigated.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1158: From nociception to chronic pain: Structure-function properties of neural pathways and their reorganisation
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Professor Dr. Stefan Lechner; Professor Dr. Martin Schmelz