Septin-dependent compartmentalization of BMP2-signaling in cell migration
(A20*)
Subject Area
Cell Biology
Term
from 2015 to 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 184695641
BMP signaling is determined by the composition, oligomerisation and lateral mobility of BMP receptors at the plasma membrane. Our preliminary work suggests that spatial segregation of distinct signaling routes is achieved by SEPT9 scaffolds and thereby important for cell fate decisions. The overall goal of project A20 is to understand the molecular basis for the septin-scaffold in the spatial and functional organization of BMP2 signaling by (1) characterizing the molecular mechanism and composition of SEPT9/BMP receptor and SEPT9/Smad interactions, (2) studying the lateral mobility of BMP receptors in a SEPT9 context using single molecule tracking, and (3) by investigating the impact of SEPT9 scaffolds on the functional outcome of BMP signaling.
DFG Programme
Collaborative Research Centres
