Overcoming intestinal immune dysregulation by metabolic modification during acute graft-versus-host disease (B09)

Subject Area Hematology, Oncology
Rheumatology
Term since 2015
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 256073931
 

Project Description

The Projekt B09,will follow the hypothesis that one of the factors leading to the immunopathology of graft-versus-host disease (GvHD) is a dysregulated intestinal metabolite milieu. They aim to study how the decline of certain metabolites, including linoleic acid and oleic acid, contributes to the impaired immunosuppressive function of immunoregulatory cells during aGvHD. For this, they will use cell culture approaches, murine aGvHD models, genetic mouse models and aGvHD patient samples.
DFG Programme Collaborative Research Centres
Subproject of SFB 1160:  Immune-mediated pathology as a consequence of impaired immune reactions (IMPATH)
Applicant Institution Albert-Ludwigs-Universität Freiburg
Project Heads Dr. Natalie Köhler; Professor Dr. Robert Zeiser