Project Details
Projekt
Impaired phagocyte function in the immunopathogenesis of systemic lupus erythematosus (SLE): Etiology and therapeutic intervention (P12)
Subject Area
Rheumatology
Term
from 2015 to 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 256073931
This proposal aims at exploring the mechanisms causing impaired phagocytosis of dying/dead cells by monocytes/macrophages, which may contribute to the immunopathogenesis of SLE. We will investigate the role of vitamin D and type I interferon pathways in regulating apoptotic cell uptake and cytokine secretion by human and mouse myeloid cells in vitro and in murine lupus models in vivo. Further, we will dissect the mechanisms by which type I interferons modulate the development, apoptotic cell clearing capacity and the downstream immune responses of phagocytic subsets in vivo. Finally, we will develop therapeutic strategies to restore clearance of dying cells as a means to correct immunopathology in murine lupus models.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1160:
Immune-mediated pathology as a consequence of impaired immune reactions (IMPATH)
Applicant Institution
Albert-Ludwigs-Universität Freiburg
