Tipping the balance: Immune-mediated pathologies in CVID enteropathy (A04 (P07))

• Subject Area: Clinical Immunology and Allergology
• Term: from 2015 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 256073931

Immune-mediated gastrointestinal disease is a severe complication in patients with common variable immunodeficiency. The current findings suggest a dysbalance of T cell mediated immunity in the context of hypogammaglobulinemia affecting the local IgA production and microbiome causing the enteropathy. By the cross-sectional and longitudinal analysis of central factors in the local, dysregulated interferon network, the TCR specificity of infiltrating T cells and comparison to autoimmune enteropathy and gastrointestinal graft-versus-host disease, the project aims to improve diagnostics and to define targets for treatment.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1160: Immune-mediated pathology as a consequence of impaired immune reactions (IMPATH)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Professor Dr. Bodo Grimbacher, until 6/2019; Professor Dr. Klaus Warnatz