Project Details
Projekt
Prospectiv controlled study of singeltons (and multiples) born after intracytoplasmic sperm injection aged 14 to 16 years and their mothers
Applicant
Professor Dr. Alexander Katalinic
Subject Area
Reproductive Medicine, Urology
Epidemiology and Medical Biometry/Statistics
Epidemiology and Medical Biometry/Statistics
Term
from 2015 to 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 273685972
The German ICSI follow-up I study showed an increased risk of malformation in children after intracytoplasmic sperm injection (ICSI) compared with cases of spontaneous conception. In the ICSI follow-up study II which examined term-born singletons after ICSI at the age of 4-6 years regarding their intellectual and physical development no differences could be found in comparison with cases of spontaneous conception at the same age. However the question is discussed, whether with increasing age, metabolic and hormonal aspects could be of importance. Therefore, in the ICSI follow-up III study we will examine the cohort of children conceived by ICSI who are now at the age of 14-16 years regarding their metabolic and endocrinological health as well as their growth and puberty development in comparison to age and sex-matched cases with spontaneous conception. Furthermore, the metabolic health of the mother will be examined.Additional questions affect the current health status, acute or chronic diseases, hospitalizations and surgeries of the children as well as the psycho-emotional situation in the family, the clarification of the conception and academic development. For the latter questions we will not only compare the singletons born after ICSI with cases of spontaneous conception but also with multiples born after ICSI.In our prospective controlled study mothers and their term-born singletons of the ICSI group, of the control group, and mothers and their multiples born after ICSI should complete a questionnaire (online or paper and pencil). A sub cohort of mothers and their term-born singletons of the ICSI group and of the control group should be examined by their related pediatric physician concerning physical health and metabolic and endocrinological status. For analyses the children will be matched by age, position in the rank of siblings, age of the mother and social status. Due to the fact that the number of families with multiples is low, we will not match them with cases of spontaneous conception. Therefore we constrain the physical and metabolic examination to singletons.The results of the study will contribute to improve the knowledge of long term effects of assisted reproductive technologies especially of ICSI. This knowledge may substantially influence the counseling of parents planning to undergo ICSI and also be important for ICSI children for their own health and reproductive future.
DFG Programme
Research Grants
