Immune complex mediated and IgG Fc receptor-dependent recruitment of leukocytes into the skin (C02+)

• Subject Area: Dermatology
• Term: from 2015 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 246807620

The formation of immune complexes by immunglobulins and their subsequent binding to Fc-receptors is of central relevance for the induction of protective humoral immune responses in the skin. Immune complexes have important immunoregulatory properties. Our studies demonstrate the relevance of immune complexes for activating a directed migration of Fcγ-expressing leukocytes. Using different Fcγ-receptor deficient leukocytes and in vivo infection- and autoimmune models, we will study the immunologic relevance and the molecular mechanisms of immune complex-directed migration in skin.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 156: The skin as sensor and effector orchestrating local and systemic immunity
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Dr. Florina Olaru; Professor Dr. Knut Schäkel