Regulation of Th17-mediated skin inflammation by heme oxygenase 1 and inflammasome activation (A06)

• Subject Area: Dermatology
• Term: from 2015 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 246807620

During skin inflammation the generation of reactive oxygen species (ROS) can influence keratinocytes and myeloid cells. On the one hand ROS affect inflammasome activation, IL-1 production and subsequent Th17 responses. On the other hand ROS-inducing conditions in antigen presenting cells induce heme oxygenase 1 (HO-1), prevent the development of pathogenic Th17 cells and related inflammation. By using conditional mice and models of Th17-skin inflammation we want to decipher the interplay between ROS, HO-1 and the inflammasome complex in myeloid cells and keratinocytes and their consequences for Th17 responses.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 156: The skin as sensor and effector orchestrating local and systemic immunity
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Co-Applicant Institution: Eberhard Karls Universität Tübingen
• Project Heads: Professor Dr. Kamran Ghoreschi; Professor Dr. Amir Sadegh Yazdi