Neuroplastic events are activated in ontogenesis, and can be recruited by disease and experimental or pharmacological manipulation. It is the aim of this research training group to study how to induce and control plasticity in the nervous system, and to derive new therapeutic strategies from this research. Towards this end, functionally beneficial plasticity, which supports recovery of function will be distinguished from maladaptive plasticity such as in phantom pain, dyskinesias, and dystonic movement disorders.Scientists of different disciplines will provide interdisclipinary teaching on the mechanisms of neuroplasticity, with particular emphasis on the interactions between clinical and basic research (biophysics, biochemistry, neurobiology, pharmacology) in an area that has been somewhat neglected in more traditional programs.A major aim of the 11 projects which cover essential aspects of neuroplasticity will be to encourage application of basic research findings to clinical medicine. To this end, the course will be carried out in close proximity to a clinical environment and will involve patients suffering from movement disorders, epilepsy, stroke, depression, pain and other disorders. Basic research will explore the physiological, chemical and anatomical mechanisms of neuroplasticity, whilst the clinical application will focus on therapeutic strategies that support functionally beneficial plasticity or suppress maladaptive plasticity. Controlled modulation of neuroplasticity, e.g. through (motor) learning or neuropharmacological intervention, will be documented by modern neuroimaging and electrophysiological techniques.
DFG Programme
International Research Training Groups
International Connection
United Kingdom
