Project Details
Projekt
In vivo application, biomechanical evaluation
Applicants
Dr. Andreas Kampmann; Privatdozentin Dr. Janin Reifenrath, since 1/2019
Subject Area
Orthopaedics, Traumatology, Reconstructive Surgery
Term
from 2015 to 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 251503496
TP8 comprises the in vivo testing of graded implants in various animal models, as well as investigations regarding the tissue integration and the biomechanical stability of graded implants in chronic tendon ruptures. The implants which are developed by the researcher unit can only reach clinical relevance, when their efficacy and harmlessness has been tested and proven in animal models. The overall aim is the development and selection of a graded implant, for which a biological integration can be proven in terms of a functional vascularization and a reconstitution of the fibrocartilaginous transition zone. Regarding biomechanical properties the implant has to exhibit >40% of the native tendon load capacity after a healing phase of three months. Until now, these parameters are not sufficiently reached in previous studies. Based on the results obtained in the first funding period, the development of graded implants will be proceeded and further implant variants will be developed in close interaction with the other subprojects. Refined implant variants will be tested regarding biocompatibility, integration into the surrounding tissue and functionality in various in vivo models. Prior to large animal experiments, different variations and developments of graded implants will be evaluated in rodent models and results will be reported back and reflected to the other related subprojects for further optimization. Parameters that will be modified during this developmental process are e.g. the effect of an enhanced local density of porosity, the impact of hybrid structures and the functionality of drug release systems in vivo.As a first step onto translation into the clinic, the most promising implant variant will be verified in the sheep model, which best reflects the human situation. The methodology requirements for these time-consuming studies are provided in the ongoing first funding period.
DFG Programme
Research Units
Co-Investigators
Privatdozent Dr. Frank Tavassol; Dr. Bastian Welke
Ehemaliger Antragsteller
Privatdozent Dr. Mathias Wellmann, until 1/2019
