The role of Gq-dependent signaling for pacemaking, impulse propagation and contractility of the heart (A19)

• Subject Area: Anatomy and Physiology
• Term: from 2015 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 157660137

A novel algorithmic approach, CaCLEAN, provides functional 3D maps of excitation-contraction coupling couplons in beating cardiomyocytes and thus further enlightens remodeling processes in cardiac diseases. In the heart, specific in vivo activation of Gq-coupled signaling via design receptors (DREADD) alters impulse-generation and -propagation and coordinated delivery. Thus, Gq-coupled signaling directly modifies cardiac electrophysiology such as intercellular communication. DREADDs will advance our understanding of the dynamic modulatory impact of Gq signaling in the in vivo heart.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 894: Ca2+-Signalling: Molecular Mechanisms and Integrative Functions
• Applicant Institution: Universität des Saarlandes
• Project Head: Professor Peter Lipp, Ph.D.