Extracellular matrix after acute cardiac ischemia: Mechanisms of hyaluronan-mediated protection (A08)

Subject Area Cardiology, Angiology
Term from 2015 to 2023
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 236177352
 

Project Description

The project aims to deepen the mechanistic understanding of the beneficial effects of hyaluronan (HA) matrix in cardiac ischemia. Therefore, the role of RHAMM (receptor of HA-mediated motility) will be unraveled using transgenic mice. It will be tested whether further increase of local HA/HA-signaling post-I/R by either deletion of hyaluronidases 1/-2 or overexpression of HA-synthase 2 will improve cardiac function. Furthermore, we ask whether the healing response post-I/R in T2DM is interrelated with cardiac HA synthesis. Finally, chemical exchange saturation transfer imaging will be applied to monitor early cardiac HA in large animals as a potential biomarker.
DFG Programme Collaborative Research Centres
Subproject of SFB 1116:  Master switches in cardiac ischemia
Applicant Institution Heinrich-Heine-Universität Düsseldorf
Project Head Professor Dr. Jens W. Fischer