Mechanism of IGF1-dependent modulation of myeloid cell function and metabolism in acute myocardial infarction
(A06)
Subject Area
Cardiology, Angiology
Term
from 2015 to 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 236177352
It was shown previously that short-term IGF1 treatment after acute myocardial infarction reduces scar size, enhances angiogenesis, and improves cardiac function via modulation of myeloid cells. In the next period the project aims at i) identification of the cell type being responsible for this effect (macrophages, neutrophils), ii) elucidation of the molecular alterations induced by IGF1 in these cells, and iii) investigation of the IGF1-mediated cardioprotection in the context of insulin resistance/ T2DM as a relevant comorbidity in AMI. In summary, the project will identify novel mechanisms of immune cell modulation which improve the outcome after AMI.
DFG Programme
Collaborative Research Centres
