Project Details
Projekt
Studies on the role of ALOX15 and its products in murine experimental colitis.
Subject Area
Gastroenterology
Term
from 2015 to 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 269515244
Preliminary unpublished data from our laboratories show that mice with a systemic knockout of the alox15 gene (12/15-lipoxygenase deficient mice) are protected from DSS-induced colitis.The main objective of the proposed project are: (1) to understand the role of alox15 in the pathogenesis of DSS-induced colitis in mice and to validate these findings on other murine colitis models, and (2) to characterize in a cell culture model the molecular mechanisms of the effect of 12/15-lipoxygenase activity and its metabolites on the function of intestinal cells.Given that the preliminary data showing a pro-inflammatory effect of ALOX15 colitis can be confirmed, and the underlying molecular pathomechanisms be identified, selective inhibitors of ALOX15 could be potential drugs for the treatment of inflammatory bowel diseases.
DFG Programme
Research Grants
