The effect of synaptic short-term plasticity on granule cell activity in the dentate gyrus microcircuit (A02)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2015 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 243553651

Odors are represented in the olfactory bulb by spatiotemporal patterns of multiple glomeruli, corresponding to ensembles of active Mitral cells. Different, yet similar odors share active Mitral cells, resulting in overlapping patternsIt has been hypothesized that GABAergic cells play a central role for decorrelation of similar activity patterns in the OB. In this project, we will analyse by in vivo calcium-imaging of Mitral cells activity and by behavioural testing how GABAergic periglomerular cells influence ensemble activity and odor discrimination.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1134: Functional ensembles: cellular components, patterned activity and plasticity of co-active neurons in local networks
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Co-Applicant Institution: Deutsches Krebsforschungszentrum (DKFZ)
• Project Head: Professor Dr. Jakob von Engelhardt