Project Details
Projekt
The role of the nephronophthisis Anks6 module in development and tissue homeostasis (B01)
Subject Area
Nephrology
Term
from 2015 to 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 246781735
Mutations of NPH proteins (NPHP) cause nephronophthisis (NPH), an autosomal recessive form of cystic kidney disease accompanied by multiple extrarenal manifestations. NPH is caused by mutations in more than 16 different gene products implementing various cellular functions by acting as a network. This project will examine the regulation of the Anks6 (NPHP16)-protein network and its involvement in developmental biological processes and the control of the cell cycle and DNA damage response. In addition we will test the hypothesis if the Anks6-complex influences the cell and energy metabolism by interacting with mitochondria.
DFG Programme
Collaborative Research Centres
Applicant Institution
Albert-Ludwigs-Universität Freiburg
Project Heads
Professor Dr. Bernd Kammerer; Professor Dr. Gerd Walz
