Project Details
Die Rolle der verschiedenen Sphingosin 1-Phosphat (S1P) Rezeptorsubtypen bei Entzündungsprozessen in vitro und in vivo bei entzündlichen Nierenerkrankungen
Applicant
Professorin Dr. Andrea Huwiler (†)
Subject Area
Pharmacology
Term
from 2006 to 2010
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 26333961
Final Report Year
2010
Final Report Abstract
No abstract available
Publications
-
(2006) The immunomodulatory FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor (CTGF) and collagen type IV expression in renal mesangial cells. Br. J. Pharmacol. 147, 164-174
Xin, C., Ren, S., Eberhardt, W., Pfeilschifter, J. and Huwiler, A.
-
(2007) FTY720 suppressesinterleukin-1b-induced secretory phospholipase A2 expression in renal mesangial cells by a transcriptional mechanism. Br. J. Pharmacol. 150, 943-950
Xin, C., Ren, S., Eberhardt, W., Pfeilschifter, J. and Huwiler, A.
-
(2007) Sphingosylphosphorylcholine exerts anti-inflammatory activity in renal mesangial cells by downregulating interleukin-1β-induced prostaglandin E2 formation. J. Lipid Res. 48, 1985-1996
Xin, C., Ren, S., Eberhardt, W., Pfeilschifter, J. and Huwiler, A.
-
(2008) Mesangial cells derived from sphingosine kinase 1 and 2 deficient mice display opposite behaviour to apoptotic stimuli. Biol. Chem., 389, 1399-1407
Hofmann, L.P., Ren, S., Schwalm, S., Pfeilschifter, J. and Huwiler, A.
-
(2009) Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P(3) in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone. J. Mol. Med. 87, 645-657
Nieuwenhuis B, Lüth A, Chun J, Huwiler A, Pfeilschifter J, Schäfer-Korting M, Kleuser B
-
(2009) Transforming growth factor-β2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-β2 by impeding CTGF expression. Kidney Int. 76, 857-867
Ren, S., Babelova, A., Moreth, K., Xin, C., Eberhardt, W., Doller, A., Pavenstädt, H., Schaefer, L., Pfeilschifter, J. and Huwiler, A