No abstract available
Publications
-
(2008) Mesangial cells derived from sphingosine kinase 1 and 2 deficient mice display opposite behaviour to apoptotic stimuli. Biol Chem, 389: 1399-1407
Hofmann LP, Ren S, Schwalm S, Pfeilschifter J, Huwiler A
-
(2008) Sphingolipids take the center stage: Sphingosine 1-phosphate and its receptors as new drug targets, Biochem Pharmacol 75: 1893-1900
Huwiler A, Pfeilschifter J
-
(2008) Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells. Biochim Biophys Res Commun 368: 1020-1025
Schwalm S, Döll F, Römer I, Bubnova S, Pfeilschifter J, Huwiler A
-
(2009) Involvement of the ABC-transporter ABCC1 and the sphingosine-1-phosphate receptor subtype S1P3 in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone. J Mol Med 87: 645-657
Nieuwenhuis B, Lüth A, Huwiler A, Chun J, Pfeilschifter J, Schäfer-Korting M, Kleuser B
-
(2009) The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia. Biochem Biophys Res Commun, 389: 251-256
Czech B, Pfeilschifter W, Omrani NM, Strobel MA, Kahles T, Neumann-Haefelin T, Rami A, Huwiler A, Pfeilschifter J
-
Transforming growth factor-β2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-β2 by impeding CTGF expression. Kidney Int 76: 857-867
Ren S, Babelova A, Moreth K, Xin C, Eberhardt W, Doller A, Pavenstädt H, Schaefer L, Pfeilschifter J Huwiler A
-
(2010) A novel mode of action of the putative sphingosine kinase inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole (SKI II): induction of lysosomal sphingosine kinase 1 degradation. Cell Physiol Biochem, 26: 97-104
Ren S, Xin C, Pfeilschifter J, Huwiler A
-
(2010) Glucocorticoids protect renal mesangial cells from apoptosis by increasing cellular sphingosine-1-phosphate levels. Kidney Int 77: 870-879
Förster A, Emmler T, Schwalm S, Ebadi M, Meyer zu Heringdorf D, Nieuwenhuis B, Kleuser B, Huwiler A, Pfeilschifter J
-
(2010) Nitric oxide upregulates sphingosine kinase-1 expression and activity in the human endothelial cell line EA.hy 926 and critically regulates endothelial tube formation. Br J Pharmacol 160: 1641-1651
Schwalm S, Pfeilschifter J, Huwiler A
-
20100311843A1: Compositions and methods for the treatment of glomerulonephritis
B. Johansen, A. Huwiler
-
(2011) A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders. PLOS One, 6: e22436
Huwiler A, Bourquin F, Kotelevets N, Pastukhov O, Capitani G, Grütter MG, Zangemeister-Wittke U
-
(2011) Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia. Biochem Biophys Res Commun. 413: 212-217
Pfeilschifter W, Czech-Zechmeister B, Sujak M, Mirceska A, Koch A, Rami A, Steinmetz H, Foerch C, Huwiler A, Pfeilschifter J
-
EP2505589 A1: Novel sphingolipid heterocyclic compounds as modulators of sphingolipid signaling and uses thereof
Stark, H., Zivkovic, A., Pfeilschifter, J., and Huwiler, A
-
PCT/EP2011/071446: Use of prokaryotic sphingosine-1-phosphate lyases and of sphingosine-1-phosphate lyases lacking a transmembrane domain for treating hyperproliferative and other diseases
Zangemeister-Wittke U., Huwiler, A., Bourquin, F., and Grütter, M
-
(2013) Dual role of sphingosine kinase 1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells. Oncogene
Albinet V, Bats M-L, Huwiler A, Rochaix P, Chevreau C, Segui B, Levade T, Andrieu-Abadie N
-
(2013) Sphingosine-1-phosphate: a Janus-faced mediator of fibrotic diseases. Biochim Biophys Acta - Mol Cell Biol Lipids 1831: 239-250
Schwalm S, Pfeilschifter J, Huwiler A
-
(2013) Targeting the sphingosine kinase/ sphingosine 1-phosphate pathway to treat chronic inflammatory kidney diseases. Basic and Clinical Pharmacology and Toxicology
Schwalm S, Pfeilschifter J, Huwiler A
DFG Programme
Research Units
International Connection
Switzerland
