Regulation of endothelial aquaporin-1 channels by reactive glucose metabolites (B04)

• Subject Area: Nephrology
• Term: from 2014 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 236360313

Reactive metabolites are of key significance for damaging the peritoneal membrane in peritoneal dialysis (PD) which results in ultrafiltration failure. Endothelial aquaporin-1 (AQP1) channels play a central role in this process. Therefore, an endothelial specific AQP1-knockout mouse will be generated and characterized to investigate the physiological relevance of AQP1 in a PD mouse model and in isolated primary endothelial cells. Analysis of human peritoneal biopsies of PD patients will also be performed to elucidate the pathophysiological relevance of AQP1.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1118: Reactive metabolites as a cause of diabetes complications
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professor Dr. Vedat Schwenger