Reactive metabolites are of key significance for damaging the peritoneal membrane in peritoneal dialysis (PD) which results in ultrafiltration failure. Endothelial aquaporin-1 (AQP1) channels play a central role in this process. Therefore, an endothelial specific AQP1-knockout mouse will be generated and characterized to investigate the physiological relevance of AQP1 in a PD mouse model and in isolated primary endothelial cells. Analysis of human peritoneal biopsies of PD patients will also be performed to elucidate the pathophysiological relevance of AQP1.
DFG Programme
Collaborative Research Centres
