TRPC cation channels in hypoglycemia-associated autonomic nervous system failure in diabetes models
(B02)
Subject Area
Pharmacology
Endocrinology, Diabetology, Metabolism
Term
from 2014 to 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 236360313
In B02 we aim to identify relevant neurons and neuroendocrine cells in the brain stem and adrenal medulla, respectively, that rely on TRPC channels during sympatho-adrenal counter-regulation to hypoglycemia. TRPC channel functions and their impact for cellular Ca2+ homeostasis and Ca2+ dependent exocytosis of catecholamines will be analysed. Based on hitherto and further metabolome studies the project aims to develop new interventional therapeutic approaches for „Hypoglycemia-associated autonomic failure“.
DFG Programme
Collaborative Research Centres
