Methylglyoxal Metabolism and its Cellular Consequences (A04)

• Subject Area: Endocrinology, Diabetology, Metabolism ; Biochemistry ; Clinical Neurology; Neurosurgery and Neuroradiology ; Cell Biology
• Term: from 2014 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 236360313

The central aim of the A04 is to investigate the cellular effects of methylglyoxal (MG), in particularly the consequences from the nuclear accumulation of the MG-derived modification, MG-H1, and the resulting unresponsive or stunned cellular phenotype. Through the use of the different model organisms available within the consortium, this project seeks to determine whether MG-induced cellular stunning/paralysis is a new hallmark of cellular dysfunction, leading to alterations in tissue homeostasis as well as cell-to-cell interactions, thereby contributing to the pathogenesis of late diabetic complications.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1118: Reactive metabolites as a cause of diabetes complications
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Dr. Thomas Henry Fleming; Professor Dr. Peter Nawroth, until 6/2018