Multiscale modeling and simulation of spatio-temporal master equations (C03)

• Subject Area: Mathematics ; Statistical Physics, Nonlinear Dynamics, Complex Systems, Soft and Fluid Matter, Biological Physics
• Term: since 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 235221301

Project C03 is focused on developing hybrid modeling approaches for reaction systems with cascades of temporal, population and spatial scales. These models will be derived and analyzed on an abstract level using mathematical methods. As one application, we will consider the ligand-based activation, aggregation and organization kinetics of receptors on cell surfaces coupled to intra- and extra-cellular signaling cascades. Two models will be constructed, one spatio-temporal hybrid model oriented towards the signaling-induced receptor activation, and another model for large-scale membrane dynamics based on interacting-particle reaction dynamics (iPRD) simulations.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1114: Scaling Cascades in Complex Systems
• Applicant Institution: Freie Universität Berlin
• Project Heads: Professor Dr. Felix Höfling, from 4/2017 until 6/2022; Professor Dr. Roland Netz, since 10/2022; Professor Dr. Frank Noé, until 9/2022; Professor Dr. Christof Schütte; Dr. Stefanie Winkelmann, since 7/2022