The kinase-coupled TRPM7 channel as a regulator of immune system homeostasis (P14)

• Subject Area: Pharmacology
• Term: since 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 239283807

TRPM7 is essential for immune system homeostasis. We found that its enzymatic activity is required for homing of lymphocytes to the gut and pro-inflammatory T-helper-17 cell differentiation. Here, we will test whether the TRPM7 kinase affects the homeostasis of resident leukocytes in the lung as well as their recruitment upon acute infection. We will assess the effect of kinase inhibition on leukocyte infiltration in in vivo models of pneumonia. Moreover, we will employ artificial intelligence in our screen for new TRPM7 kinase inhibitors. This will further highlight TRPM7 as potential therapeutic target for the treatment of inflammatory diseases.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 152: TRiPs to Homeostasis: Maintenance of Body Homeostasis by Transient Receptor Potential Channel Modules
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Dr. Susanna Zierler