TRPC channels in synaptic short-term plasticity and secretion (P07)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 239283807

TRPC1, TRPC4 and TRPC5 channels form heteromeric non-selective cation channels, which are highly expressed in brain and neuroendocrine cells. Recently, we identified TRPC channels as crucial regulators of presynaptic Ca2+-dynamics and short-term plasticity. Furthermore, we show that TRPC5 channels play an important role in catecholamine release from mouse chromaffin cells. This project sets out to unravel how TRPCs engage in macromolecular complexes that regulate presynaptic Ca2+-homeostasis, synaptic plasticity and stress-induced catecholamine secretion from neuroendocrine cells.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 152: TRiPs to Homeostasis: Maintenance of Body Homeostasis by Transient Receptor Potential Channel Modules
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Professor Dr. Dieter Bruns; Yvonne Schwarz, Ph.D., since 7/2018