Role of Lipid Mediators in Complex Host Cell-Microbe Interactions (A04)

• Subject Area: Pharmacy ; Biological and Biomimetic Chemistry ; Cell Biology
• Term: since 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 239748522

We investigate how functionally different M1 and M2 macrophage phenotypes communicate with each other to combat microbial infections and to restore tissue homeostasis in the host. We focus on lipid mediators as signal molecules that are formed by microbial exotoxins in macrophages and thus control phagocytes and other immune cells in the defense against infection. We evaluate if the targeted manipulation of lipid mediators with active ingredients, especially natural products from other organisms, can be used to modulate cellular host functions in such a way that microbial infections are effectively combated and that homeostasis is restored.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1127: Chemical Mediators in Complex Biosystems (ChemBioSys)
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Heads: Professor Dr. Pierre Stallforth, until 6/2022; Professor Dr. Oliver Werz