Structural and cellular characterization of bone marrow interfaces under the influence of adi-pogen factors in bone replacement material testing ((16) B11)

• Subject Area: Orthopaedics, Traumatology, Reconstructive Surgery
• Term: from 2014 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 107540325

In B11, the interaction of adipokines and free fatty acids concerning osteoporosis and osseointegration of biomaterials is under investigation. The detailed analysis of osteogenic and adipogenic differentiation of mesenchymal stem cells with and without spongiosa transfer with regard to adipokines and osteoprotective drugs shall be completed. Moreover the influence of visfatin to the adiopogenic and osteogenic cell differentiation at the biomaterials interface is under investigation. In an osteoporotic animal model, the effect of visfatin alteration will be evaluated. By using mass spectrometric imaging we will analyse the lipid composition of the cell membrane and in bone itself after contact with biomaterials and adipokines.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 79: Materials for Tissue Regeneration within Systemically Altered Bone
• Applicant Institution: Justus-Liebig-Universität Gießen
• Project Heads: Professor Dr. Ulf Müller-Ladner; Privatdozentin Dr. Elena Neumann; Professor Dr. Marcus Rohnke; Professor Dr. Reinhard Schnettler, until 12/2017; Professorin Dr. Sabine Wenisch, until 12/2017