Chromatin regulation by BAF complex controls cortical astrogenesis
Final Report Abstract
Astrocytes constitute the largest cell population in the human brain and are crucial for the brain development. Defects in astrogenesis are linked with neurological disorders such as Rett syndrome, fragile X syndrome, and brain tumors. Therefore, it is important to understand how astrocytes are generated. The ATP-dependent multi-subunit BAF (known as SWI/SNF) chromatin remodeling complexes are crucial in regulating gene expression by controlling chromatin dynamics. By interacting with epigenetic modifying enzymes, BAF complex also controls distinct epigenetic programs. By using a combination of genomic, proteomic approaches and advanced genetic manipulation and in the frame of the DFG –funded project, our research is aimed: (1) to characterize the astrocytic phenotypes of BAF170 mutant mice, (2) to study the BAF170-dependent mechanisms that control astrocytic development. The experiments have been completed as planned; the aims of study were be achieved.
Publications
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(2018) Transcriptional and Epigenetic Control of Mammalian Olfactory Epithelium Development. Molecular neurobiology 55 (11) 8306–8327
Sokpor, Godwin; Abbas, Eman; Rosenbusch, Joachim; Staiger, Jochen F.; Tuoc, Tran
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Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development. Cell Rep, 2015. 13(9): p. 1842-54
Narayanan R, Pirouz M, Kerimoglu C, Pham L, Wagener RJ, Kiszka KA, Rosenbusch J, Seong RH, Kessel M, Fischer A, Stoykova A, Staiger JF, and Tuoc T
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Epigenetic regulation by BAF (mSWI/SNF) chromatin remodeling complexes is indispensable for embryonic development. Cell cycle, 2016. 15(10): p. 1317- 24
Nguyen H, Sokpor G, Pham L, Rosenbusch J, Stoykova A, Staiger JF, and Tuoc T
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mSWI/SNF (BAF) Complexes Are Indispensable for the Neurogenesis and Development of Embryonic Olfactory Epithelium. PLoS genetics, 2016. 12(9): p. e1006274
Bachmann C, Nguyen H, Rosenbusch J, Pham L, Rabe T, Patwa M, Sokpor G, Seong RH, Ashery-Padan R, Mansouri A, Stoykova A, Staiger JF, and Tuoc T
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Ablation of BAF170 in Developing and Postnatal Dentate Gyrus Affects Neural Stem Cell Proliferation, Differentiation, and Learning. Mol Neurobiol, 2017. 54(6): p. 4618-4635
Tuoc T, Dere E, Radyushkin K, Pham L, Nguyen H, Tonchev AB, Sun G, Ronnenberg A, Shi Y, Staiger JF, Ehrenreich H, and Stoykova A
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Chromatin Remodeling BAF (SWI/SNF) Complexes in Neural Development and Disorders. Front Mol Neurosci, 2017. 10: p. 243
Sokpor G, Xie Y, Rosenbusch J, and Tuoc T
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ATP- Dependent Chromatin Remodeling During Cortical Neurogenesis. Front Neurosci, 2018. 12: p. 226
Sokpor G, Castro-Hernandez R, Rosenbusch J, Staiger JF, and Tuoc T
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Epigenetic Regulation by BAF Complexes Limits Neural Stem Cell Proliferation by Suppressing Wnt Signaling in Late Embryonic Development. Stem Cell Reports, 2018. 10(6): p. 1734-1750
Nguyen H, Kerimoglu C, Pirouz M, Pham L, Kiszka KA, Sokpor G, Sakib MS, Rosenbusch J, Teichmann U, Seong RH, Stoykova A, Fischer A, Staiger JF, and Tuoc T
