Cellular mechanisms of lesion-induced pretectal visuo-motor plasticity in adult zebrafish
(A12)
Subject Area
Molecular Biology and Physiology of Neurons and Glial Cells
Cognitive, Systems and Behavioural Neurobiology
Term
from 2014 to 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 118803580
The horizontal optokinetic reflex in zebrafish is direction-specifically impaired after a unilateral stab wound injury of a pretectal nucleus that causes cell death in this area. The lack of recovery in 70% of the animals suggests a differential activation of cellular reactions and reorganization of sensory weighting. This proposal aims to decipher post-lesional processes such as neurogenesis, inflammation, glial reactivity and sensory substitution in regeneration-competent and incompetent groups. The outcome will reveal the role of cellular/molecular alterations and principles of cross-modal plasticity for a functional recovery after brain injury.
DFG Programme
Collaborative Research Centres
