Evaluierung der Wirksamkeit eines neuartigen RIA/mPCL-TCP Scaffold-Systems zur Behandlung kritischer segmentaler Knochendefekte im Vergleich zum Goldstandard des autologen Knochentransplantates am Schaf-Großtiermodell

• Antragsteller: Dr. Jan Henkel
• Fachliche Zuordnung: Orthopädie, Unfallchirurgie, rekonstruktive Chirurgie ; Biomaterialien ; Herstellung und Eigenschaften von Funktionsmaterialien
• Förderung: Förderung von 2013 bis 2015
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 249847580

The incidence and burden of bone fractures is a global public health issue. Fractures of the tibia are among the prevalent anatomical sites afflicted, with non-union rates of 14%. This not only prolongs the treatment duration but also extends the overall years of impairment for those affected, resulting in significant healthcare costs. The current gold standard treatment relies on autologous bone grafts, mainly harvested from the iliac crest (ICBG), and from the intramedullary canal of long bones via the Reamer-Irrigator-Aspirator (RIA) System. Viably comparable to the conventional ICBG treatment the latter stands out for its ability to collect substantial volumes of intramedullary bone graft with associated osteogenic properties. However, both approaches face constrains including limited availability, post-operative complications, and donor site morbidities. These inherent challenges have spurred the search for treatment solutions rooted in tissue engineering. Scaffold guided bone tissue engineering (SGBTE) has emerged as a promising alternative strategy to fulfill the escalating demand for bone graft material among orthopaedic surgeries. Utilizing QUTs well-established sheep animal model and the unique benefits of mPCL-TCP scaffolds in retaining and compartmentalizing autologous bone grafts (harvested with the Reamer-Irrigator-Aspirator-System, RIA, Depuy Synthes) within the scaffold matrix, this study aimed at exploring the feasibility of using a reduced volume of RIA bone graft for scaffold guided bone tissue engineering for the treatment of a 6cm critical-sized tibial bone defects in sheep.

• DFG-Verfahren: Forschungsstipendien
• Internationaler Bezug: Australien
• Gastgeber: Professor Dr. Dietmar W. Hutmacher, Ph.D.; Professor Dr. Michael Schütz