Cortical network dysfunctions in response to hyperstimulated Neuregulin/ErbB4 signaling

• Applicant: Privatdozent Dr. Markus Hermann Schwab
• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2014 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 249113022

• Final Report Year: 2019

Final Report Abstract

No abstract available

Publications

• Dysregulated expression of neuregulin-1 by cortical pyramidal neurons disrupts synaptic plasticity. Cell Reports, Vol. 8. 2014, Issue 4, pp. 1130-1145.
  Agarwal A., Zhang M., Trembak-Duff I., Unterbarnscheidt T., Radyushkin K., Dibaj P., Martins de Souza D., Boretius S., Brzózka M.M., Steffens H., Berning S., Teng Z., Gummert M., Tantra M., Guest P.C., Willig K.I., Frahm J., Hell S.W., Bahn S., Rossner M.J., Nave K.A., Ehrenreich H., Zhang W., Schwab M.H.
  (See online at https://doi.org/10.1016/j.celrep.2014.07.026)
• Neuregulin1 displayed on motor axons regulates terminal Schwann cell-mediated Synapse elimination at developing neuromuscular junctions. Proceedings of the National Academy of Sciences of the USA, Vol. 113. 2016, Issue 4, pp. E479-E487.
  Lee Y., Li Y., Mikesh M., Smith I., Nave K.A., Schwab M.H., Thompson W.J.
  (See online at https://doi.org/10.1073/pnas.1519156113)
• OSO paradigm-A rapid behavioral screening method for acute psychosocial stress reactivity in mice. Neuroscience, Vol. 314. 2016, pp. 1-11.
  Brzózka M.M., Unterbarnscheidt T., Schwab M.H., Rossner M.J.
  (See online at https://doi.org/10.1016/j.neuroscience.2015.11.043)
• Spironolactone is an antagonist of NRG1-ERBB4 signaling and schizophrenia-relevant endophenotypes in mice. EMBO Molecular Medicine, Vol. 9. 2017, Issue 10, pp. 1448-1462.
  Wehr M.C., Hinrichs W., Brzózka M.M., Unterbarnscheidt T., Herholt A., Wintgens J.P., Soto-Bernardini M.C., Kravchenko M., Nave K.A., Wichert S.P., Falkai P., Zhang W., Schwab M.H., Rossner M.J.
  (See online at https://doi.org/10.15252/emmm.201707691)
• Altered hippocampal gene expression and structure in transgenic mice over-expressing neuregulin 1 (NRG1) type I. Translational Psychiatry, Vol. 8. 2018, Article number: 229.
  Deakin I. H., Godlewska B. R., Walker M. A., Huang G.-J., Schwab M.H., Nave K. A., Law A. J., Harrison P. J.
  (See online at https://doi.org/10.1038/s41398-018-0288-2)
• Localization and dynamic changes of neuregulin-1 at C-type synaptic boutons in association with motor neuron injury and repair. FASEB Journal, Vol. 33. 2019, No. 7, pp. 7833-7851.
  Salvany S., Casanovas A., Tarabal O., Piedrafita L., Hernández S., Santafé M., Soto-Bernardini M.C., Calderó J., Schwab M.H.*, Esquerda J.E. *joint corresponding author
  (See online at https://doi.org/10.1096/fj.201802329R)
• NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies. Nature Communications, Vol. 10. 2019, Article number: 1467.
  Fledrich R., Akkermann D., Abdelaal T.A., Schuetza V., Hermes D., Schäffner E., Soto-Bernadini M.C., Götze T., Klink A., Kusch K., Krüger M., Moebius W., Brück W., Mueller W.C., Sereda M.W., Schwab M.H.*, Nave K.A., Stassart R.M. *joint corresponding author
  (See online at https://doi.org/10.1038/s41467-019-09385-6)