B-lymphoid Nuclear Logistics (08)

• Subject Area: Immunology
• Term: from 2013 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 215346292

The B cell antigen receptor (BCR) controls the activation of naïve and memory B cells via common and BCR isotype-specific signaling mechanisms. In project 08, we elucidated several of those mechanisms, showing that the activation of naïve B cells requires the adaptor protein CIN85 whereas memory B cells depend on a BCR-intrinsic signal-amplification motif. Within the next funding period, we will extend this work to a global analysis of signal elements whose subcellular localization is controlled by BCR isotypes and co-receptors. In preliminary experiments, we identified the transcription factor TFEB as a novel B cell nucleocytoplasmic shuttling element, the function of which will be dissected in vivo and in vitro.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 130: B Cells: Immunity and Autoimmunity
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Heads: Dr. Niklas Engels; Professor Dr. Jürgen Wienands