The role of phosphatases in B cell autoimmunity (05)

• Subject Area: Immunology
• Term: from 2013 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 215346292

B cell activation is mediated by multiple tyrosine phosphorylation events that are tightly controlled by protein tyrosine phosphatases (PTPs). To better understand the role of different PTPs in hyperactivity and auto-reactivity of B cells, new substrates of the PTPs SHP-1 and PTP1B in B cells were identified by quantitative phosphoproteomic approaches. These PTP substrates will be further studied by knockouts in cell lines and their relevance will be studied in B cells from autoimmune patients. A further emphasis lies on the discovery of new phosphatases in B cell development.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 130: B Cells: Immunity and Autoimmunity
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Co-Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Professor Dr. Michael Reth; Professorin Dr. Bettina Warscheid