The resting state of B lymphocytes and their Transition into early and late activation stages (02)

• Subject Area: Immunology
• Term: from 2013 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 215346292

The project 02 studies the nanoscale organization of receptors on the surface of resting B lymphocytes. We found that on these cells the B cell antigen receptors of class IgM and IgD are localized inside distinct receptor nanocluster and that the tetraspanning membrane protein CD20 is a critical gatekeeper for the IgD class nanodomain. In the new funding period, we want to learn more about the CD20 gatekeeper function, how B cells exit the resting state and study critical regulatory circuits that regulate the B-cell to plasma cell development of Ramos B cells without CD20.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 130: B Cells: Immunity and Autoimmunity
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Heads: Professorin Susana Minguet, Ph.D.; Professor Dr. Michael Reth