The project 02 studies the nanoscale organization of receptors on the surface of resting B lymphocytes. We found that on these cells the B cell antigen receptors of class IgM and IgD are localized inside distinct receptor nanocluster and that the tetraspanning membrane protein CD20 is a critical gatekeeper for the IgD class nanodomain. In the new funding period, we want to learn more about the CD20 gatekeeper function, how B cells exit the resting state and study critical regulatory circuits that regulate the B-cell to plasma cell development of Ramos B cells without CD20.
DFG Programme
CRC/Transregios
