Mechanisms of Regulation and Information Processing by the INO80 Remodeler (A06)

• Subject Area: General Genetics and Functional Genome Biology
• Term: from 2013 to 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213249687

INO80 use the energy of ATP to modulate the position, histone composition and dynamic properties of nucleosomes. In the past funding period, we revealed structurally how INO80 binds the nucleosome and found that it is regulated in part by binding shape features in extranucleosomal DNA. Here we address, using collaborative structural and biochemical analyses, additional modes of regulation, including conformational switching and histone modifications and translate our findings to the human system. Our goal is to reveal conserved and species-specific features of INO80 and their regulation to shape promoter chromatin.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1064: Chromatin Dynamics
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Karl-Peter Hopfner