EXC 62:  From Regenerative Biology to Reconstructive Therapy (REBIRTH)

Final Report Abstract

Based on our long-standing expertise in clinical translation of basic research in particular for transplantation and regenerative medicine, the DFG-funded Cluster of Excellence REBIRTH explored biological principles for the development of regenerative therapies of genetic, acquired and degenerative diseases. The concept was carried by a consortium of Hannover´s universities (MHH, LUH, TiHo) and non-university institutes including three leading German research organisations (Fraunhofer Society, Helmholtz Society, Max Planck Society). Focusing on heart, lung, liver, and blood, we studied organ development and stem cell biology to develop therapeutic concepts for endogenous repair, and pioneered generation, modification, differentiation and cell expansion, namely of induced pluripotent stem cells. Close interaction of physicians, biologists, physicochemical scientists, and engineers facilitated the development of new concepts for cellular therapies, tissue engineering products and biohybrid devices. Next to many important publications, REBIRTH researchers placed various patent applications, created spin-off companies and initiated clinical trials, e.g. for post-partum cardiomyopathy, cell therapies for myocardial infarction and inherited immundeficiencies, and trials to implant tissue engineered heart valves with adaptive growth. Maintaining its original research structure of the first proposal in 2006, REBIRTH, from 2012 on, proceeded to utilise additional advanced platforms for cell processing, biomaterial development, imaging and biosafety assessment to accelerate the development of regenerative therapies. Participating in the definition of safety and efficacy and respecting specific ethical, clinical and regulatory prerequisites, novel concepts and study designs were specified for endogenous regeneration, cell and gene therapies, tissue engineering products, and biohybrid devices, and created added value in terms of safer and faster clinical application and economic exploitation of advanced therapies, for REBIRTH research and beyond. By promoting the cooperation with other fields of research and organ systems within our infrastructure, interdisciplinary concepts in regenerative medicine were pioneered, e.g. disease prevention and antiinfectious strategies. New tools for corporate governance were developed and greatly facilitated the management of the cluster. To develop our human resources, we expanded our educational responsibility beyond our REBIRTH’s PhD programme ‘Regenerative Sciences’, and supported programmes concerning gender equality. With this mission, and fostered by sustained support of the Land of Lower Saxony and of our institutions as well as fuelled by our own drive for excellent research, we established an innovative, sustainable, internationally visible centre for regenerative medicine. The Consortium REBIRTH will continue to exist as Research Centre for Translational Regenerative Medicine with a modified structure at the MHH with the involvement of the partner institutions.

Publications

• A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy. Cell 2007; 128:589
  Hilfiker-Kleiner D., Kaminski K., et int, Hilfiker A., Drexler H.
  
• MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 2008; 456:980
  Thum T., Gross C., et int, Bauersachs J., Engelhardt S.
  
• Cell therapy for the treatment of coronary heart disease: a critical appraisal. Nat Rev Cardiol 2010; 7:204
  Wollert K. C., Drexler H.
  
• Evaluation of bromocriptine in the treatment of acute severe peripartum cardiomyopathy: a proof-of-concept pilot study. Circulation 2010; 121:1465
  Sliwa K., Blauwet L.,et int, Hilfiker-Kleiner D.
  
• Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases. Proc Natl Acad Sci USA 2011; 108:12013
  Hauschild J., Petersen B., et int, Niemann H.
  
• Induction of BALT in the absence of IL-17. Nat Immunol 2011; 13:1; author reply 2
  Fleige H., Haas J. D., et int, Prinz I. , Förster R.
  
• MicroRNA-24 Regulates Vascularity After Myocardial Infarction. Circulation 2011; 124:720
  Fiedler J., Jazbutyte V., et int, Heineke J., Martin U., et int, Bauersachs J., Thum T.
  
• Patterning human stem cells and endothelial cells with laser printing for cardiac regeneration. Biomaterials 2011; 32:9218
  Gaebel R., Ma N., et int, Chichkov B., et int, Steinhoff G.
  
• Scalable expansion of human pluripotent stem cells in suspension culture. Nat Protoc 2011; 6:689
  Zweigerdt R., Olmer R., et int, Haverich A., Martin U.
  
• Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: a key role for ubiquitin-conjugating enzymes. Eur Heart J 2011; 32:1287
  Haghikia A., Missol-Kolka E., et int, Eder M., et int, Thum T., et int, Hilfiker-Kleiner D. , Scherr M.
  
• Use of fresh decellularized allografts for pulmonary valve replacement may reduce the reoperation rate in children and young adults: early report. Circulation 2011; 124:S115
  Cebotari S., Tudorache I., et int, Haverich A.
  
• Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. Nature 2012; 485:333
  Patten I. S., Rana S., et int, Bauersachs J., Hilfiker-Kleiner D., et int, Arany Z.
  
• Cellular Senescence Limits Regenerative Capacity and Allograft Survival. J Am Soc Nephrol 2012; 23:1467
  Braun H, Schmidt B. M. W., et int, Melk A.
  
• Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation. J Clin Invest 2012; 122:368
  Bohne F., Martinez-Llordella M., et int, Jaeckel E., et int, Sanchez-Fueyo A.
  
• Normothermic perfusion of donor lungs for preservation and assessment with the Organ Care System Lung before bilateral transplantation: a pilot study of 12 patients. Lancet 2012; 380:1851
  Warnecke G., Moradiellos J., et int, Wiegmann B., et int, Haverich A.
  
• Normothermic perfusion of donor lungs for preservation and assessment with the Organ Care System Lung before bilateral transplantation: a pilot study of 12 patients. Lancet 2012; 380:1851
  Warnecke G., Moradiellos J., Tudorache I., Kuehn C., Avsar M., Wiegmann B., Sommer W., Ius F., Kunze C., Gottlieb J., Varela A., Haverich A.
  
• Research priorities. ELSI 2.0 for genomics and society. Science 2012; 336:673
  Kaye J., Meslin E. M., et int, Hoppe N., et int, Kato K.
  
• The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy. Nat Commun 2012; 3:1078
  Ucar A., Gupta S. K., et int, Bauersachs J., et int, Thum T.
  
• Transplantation and tracking of human-induced pluripotent stem cells in a pig model of myocardial infarction: assessment of cell survival, engraftment, and distribution by hybrid single photon emission computed tomography/computed tomography of sodium iodide symporter transgene expression. Circulation 2012; 126:430
  Templin C., Zweigerdt R., et int, Olmer R., et int, Haverich A., et int,Martin U.
  
• Transplantation and tracking of human-induced pluripotent stem cells in a pig model of myocardial infarction: assessment of cell survival, engraftment, and distribution by hybrid single photon emission computed tomography/computed tomography of sodium iodide symporter transgene expression. Circulation 2012; 126:430
  Templin C., Zweigerdt R., Schwanke K., Olmer R., Ghadri J.R., Emmert M.Y., Müller E., Küest S.M., Cohrs S., Schibli R., Kronen P., Hilbe M., Reinisch A., Strunk D., Haverich A., Hoerstrup S., Lüscher T.F., Kaufmann P.A., Landmesser U., Martin U.
  
• Fully defined in situ cross-linkable alginate and hyaluronic acid hydrogels for myocardial tissue engineering. Biomaterials 2013; 34:940
  Dahlmann J., Krause A., et int, Martin U., Kirschning A., Gruh I. , Dräger G.
  
• Fully defined in situ cross-linkable alginate and hyaluronic acid hydrogels for myocardial tissue engineering. Biomaterials 2013; 34:940
  Dahlmann J., Krause A., Möller L., Kensah G., Mowes M., Diekmann A., Martin U., Kirschning A., Gruh I. , Dräger G.
  
• MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy. J Clin Invest 2013; 123:2143
  Halkein J., Tabruyn S. P., et int, Hilfiker-Kleiner D., Struman I.
  
• Murine and human pluripotent stem cell-derived cardiac bodies form contractile myocardial tissue in vitro. Eur Heart J 2013; 34:1134
  Kensah G., Roa Lara A., et int, Zweigerdt R., et int, Dräger G., Ochs M., Haverich A., Gruh I. , Martin U.
  
• Murine and human pluripotent stem cell-derived cardiac bodies form contractile myocardial tissue in vitro. Eur Heart J 2013; 34:1134
  Kensah G., Roa Lara A., Dahlmann J., Zweigerdt R., Schwanke K., Hegermann J., Skvorc D., Gawol A., Azizian A., Wagner S., Maier L.S., Krause A., Dräger G., Ochs M., Haverich A., Gruh I., Martin U.
  
• A modified gamma-retrovirus vector for X-linked severe combined immunodeficiency. N Engl J Med 2014; 371:1407
  Hacein-Bey-Abina S., Pai S. Y., et int, Schambach A., et int, Baum C., Thrasher A. J.
  
• Efficient designer nuclease-based homologous recombination enables direct PCR screening for footprintless targeted human pluripotent stem cells. Stem Cell Reports 2014; 2:107
  Merkert S., Wunderlich S., et int, Göhring G., et int, Martin U.
  
• Gene correction of human induced pluripotent stem cells repairs the cellular phenotype in pulmonary alveolar proteinosis. Am J Respir Crit Care Med 2014; 189:167
  Lachmann N., Happle C., Ackermann M., et int, Schambach A., Steinemann D., Göhring G., Cantz T., Martin U., et int, Hansen G. , Moritz T.
  
• Gene correction of human induced pluripotent stem cells repairs the cellular phenotype in pulmonary alveolar proteinosis. Am J Respir Crit Care Med 2014; 189:167
  Lachmann N., Happle C., Ackermann M., Lüttge D., Wetzke M., Merkert S., Hetzel M., Kensah G., Jara-Avaca M., Mucci A., Skuljec J., Dittrich A.M., Pfaff N., Brennig S., Schambach A., Steinemann D., Göhring G., Cantz T., Martin U., Schwerk N., Hansen G. , Moritz T.
  
• IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs. J Exp Med 2014; 211:643
  Fleige H., Ravens S., et int, Kalinke U., Prinz I., Förster R.
  
• Pathophysiology and epidemiology of peripartum cardiomyopathy. Nat Rev Cardiol 2014; 11:364
  Hilfiker-Kleiner D., Sliwa K.
  
• Prevention of rejection of allogeneic endothelial cells in a biohybrid lung by silencing HLA-class I expression. Biomaterials 2014; 35:8123
  Wiegmann B., Figueiredo C., et int, Korossis S., Haverich A. , Blasczyk R.
  
• Prevention of rejection of allogeneic endothelial cells in a biohybrid lung by silencing HLA-class I expression. Biomaterials 2014; 35:8123
  Wiegmann B., Figueiredo C., Gras C., Pflaum M., Schmeckebier S., Korossis S., Heuser A. , Blasczyk R.
  
• Pulmonary macrophage transplantation therapy. Nature 2014; 514:450
  Suzuki T., Arumugam P., et int, Lachmann N., et int, Moritz T., et int, Trapnell B. C.
  
• Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis. Sci Transl Med 2014; 6:250ra11
  Happle C., Lachmann N., Skuljec J., Wetzke M., Ackermann M., Brennig S., Mucci A., Jirmo A.C., Groos S., Mirenska A., Hennig C., Rodt T., Bankstahl J.P., Schwerk N., Moritz T., Hansen G.
  
• Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis. Sci Transl Med 2014; 6:250ra113
  Happle C., Lachmann N., et int, Ackermann M., et int, Moritz T. , Hansen G.
  
• Serum CCL18 is predictive for lung disease progression and mortality in systemic sclerosis. Eur Respir J 2014; 43:1530
  Schupp J., Becker M., et int, Prasse A.
  
• Uncoupling of the dynamics of host-pathogen interaction uncovers new mechanisms of viral interferon antagonism at the single-cell level. Nucleic Acids Res 2014; 42:e109
  Rand U., Hillebrand U., et int, Hauser H., Wirth D.
  
• Vascular importance of themiR- 212/132 cluster. Eur Heart J 2014; 35:3224
  Kumarswamy R., Volkmann I., et int, Melk A., et int, Thum T.
  
• Cardiac differentiation of human pluripotent stem cells in scalable suspension culture. Nat Protoc 2015; 10:1345
  Kempf H., Kropp C., Olmer R., Martin U., Zweigerdt R.
  
• Large-scale hematopoietic differentiation of human induced pluripotent stem cells provides granulocytes or macrophages for cell replacement therapies. Stem Cell Reports 2015; 4:282
  Lachmann N., Ackermann M., et int, Happle C., et int, Schambach A., et int, Figueiredo C., Hansen G., et int, Moritz T.
  
• Molecular Imaging of the Chemokine Receptor CXCR4 After Acute Myocardial Infarction. JACC Cardiovasc Imaging 2015; 8:1417
  Thackeray J. T., Derlin T., et int, Wollert K. C., Bauersachs J., Bengel F. M.
  
• Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction. Nat Med 2015; 21:140
  Korf-Klingebiel M., Reboll M. R., et int, Bauersachs J., Ganser A., et int, Kempf T., et int, Wollert K. C.
  
• Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction. Nat Med 2015; 21:140
  Korf-Klingebiel M., Reboll M.R., Klede S., Brod T., Pich A., Polten F., Napp L.C., Bauersachs J., Ganser A., Brinkmann E., Reimann I., Kempf T., Niessen H.W., Mizrahi J., Schonfeld H.J., Iglesias A., Bobadilla M., Wang Y., Wollert K.C.
  
• Off-target-free gene delivery by affinitypurified receptor-targeted viral vectors. Nat Commun 2015; 6:6246
  Münch R. C., Muth A., et int, Büning H., Buchholz C. J.
  
• Peripartum cardiomyopathy: current management and future perspectives. Eur Heart J 2015. 36:1090
  Hilfiker-Kleiner D., Haghikia A., et int, Bauersachs J.
  
• Successful matrix guided tissue regeneration of decellularized pulmonary heart valve allografts in elderly sheep. Biomaterials 2015; 52:221
  Theodoridis K., Tudorache I., et int, Cebotari S., et int, Haverich A., Hilfiker A.
  
• Successful matrix guided tissue regeneration of decellularized pulmonary heart valve allografts in elderly sheep. Biomaterials 2015; 52:221
  Theodoridis K., Tudorache I., Calistru A., Cebotari S., Meyer T., Sarikouch S., Bara C., Brehm R., Haverich A., Hilfiker A.
  
• Advances in clinical NK cell studies: Donor selection, manufacturing and quality control. Oncoimmunology 2016; 5:e1115178
  Köhl U., Kalberer C., et int, Alici E.
  
• Alpharetroviral self-inactivating vectors produced by a superinfection-resistant stable packaging cell line allow genetic modification of primary human T lymphocytes. Biomaterials 2016; 97:97
  Labenski V., Suerth J. D., et int, Schambach A.
  
• Alpharetroviral self-inactivating vectors produced by a superinfection-resistant stable packaging cell line allow genetic modification of primary human T lymphocytes. Biomaterials 2016; 97:97
  Labenski V., Suerth J.D., Barczak E., Heckl D., Levy C., Bernadin O., Charpentier E., Williams D.A., Fehse B., Verhoeyen E., Schambach A.
  
• Animal Study Registries: Results from a Stakeholder Analysis on Potential Strengths, Weaknesses, Facilitators, and Barriers. PLoS Biol 2016; 14:e2000391
  Wieschowski S., Silva D. S., Strech D.
  
• Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells. Nat Commun 2016; 7:13602
  Kempf H., Olmer R., et int, Göhring G., Dräger G., et int, Haverich A., Büttner F. F., Martin U., Zweigerdt R.
  
• Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells. Nat Commun 2016; 7:13602
  Kempf H., Olmer R., Haase A., Franke A., Bolesani E., Schwanke K., Robles-Diaz D., Coffee M., Göhring G., Dräger G., Potz O., Joos T., Martinez-Hackert E., Haverich A., Buettner F.F., Martin U., Zweigerdt R.
  
• Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis. Cell Stem Cell 2016; 18:797
  Song G., Pacher M., et int, Steinemann D., et int, Manns M. P., Schöler H. R., Schambach A., Cantz T., Ott M., Sharma A. D.
  
• Direct reprogramming of hepatic myofibroblasts into hepatocytes in vivo attenuates liver fibrosis. Cell Stem Cell 2016; 18:797
  Song G., Pacher M., Balakrishnan A., Yuan Q., Tsay H.C., Yang D., Reetz J., Brandes S., Dai Z., Putzer B.M., Arauzo-Bravo M.J., Steinemann D., Luedde T., Schwabe R.F., Manns M.P., Schöler H.R., Schambach A., Cantz T., Ott M., Sharma A.D.
  
• Ethics Reporting in Biospecimen and Genetic Research: Current Practice and Suggestions for Changes. PLoS Biol 2016; 14:e1002521
  Chin W. W., Wieschowski S., et int, Illig T., Strech D.
  
• In vivo killing capacity of cytotoxic T cells is limited and involves dynamic interactions and T cell cooperativity. Immunity 2016; 44:233
  Halle S., Keyser K.A., Stahl F.R., Busche A., Marquardt A., Zheng X., Galla M., Heissmeyer V., Heller K., Boelter J., Wagner K., Bischoff Y., Martens R., Braun A., Werth K., Uvarovskii A., Kempf H., Meyer-Hermann M., Arens R., Kremer M., Sutter G., Messerle M., Förster R.
  
• Investigators IMAC-2, Investigators IPAC. Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies. N Engl J Med 2016; 374:233
  Ware J. S., Li J., et int, Hilfiker-Kleiner D., et int, Arany Z.
  
• Long noncoding RNA Chast promotes cardiac remodeling. Sci Transl Med 2016; 8:326ra22
  Viereck J., Kumarswamy R., Schambach A., et int, Zweigerdt R., et int, Thum T.
  
• Long noncoding RNA Chast promotes cardiac remodeling. Sci Transl Med 2016; 8:326ra22
  Viereck J., Kumarswamy R., Foinquinos A., Xiao K., Avramopoulos P., Kunz M., Dittrich M., Maetzig T., Zimmer K., Remke J., Just A., Fendrich J., Scherf K., Bolesani E., Schambach A., Weidemann F., Zweigerdt R., de Windt L.J., Engelhardt S., Dandekar T., Batkai S., Thum T.
  
• MicroRNA- 125b-5p mimic inhibits acute liver failure. Nat Commun 2016; 7:11916
  Yang D., Yuan Q., et int, Bantel H., et int, Manns M. P., Ott M., Cantz T., Sharma A. D.
  
• MicroRNA-125b-5p mimic inhibits acute liver failure. Nat Commun 2016; 7:11916
  Yang D., Yuan Q., Balakrishnan A., Bantel H., Klusmann J.H., Manns M.P., Ott M., Cantz T., Sharma A.D.
  
• MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease. Circulation 2016; 134:1973
  Hartmann D., Fiedler J., et int, Hilfiker-Kleiner D., Lachmann N., et int, Heineke J., Bauersachs J., et int, Thum T.
  
• MicroRNA-based therapy of GATA2-deficient vascular disease. Circulation 2016; 134:1973
  Hartmann D., Fiedler J., Sonnenschein K., Just A., Pfanne A., Zimmer K., Remke J., Foinquinos A., Butzlaff M., Schimmel K., Maegdefessel L., Hilfiker-Kleiner D., Lachmann N., Schober A., Froese N., Heineke J., Bauersachs J., Batkai S., Thum T.
  
• Regulation of monocyte cell fate by blood vessels mediated by Notch signalling. Nat Commun 2016; 7
  Gamrekelashvili J., Giagnorio R., et int, Bauersachs J., et int, Limbourg F. P.
  
• Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells. Nat Commun 2016; 7:10286
  Klawitter S., Fuchs N. V., et int, Martin U., et int, Schumann G. G.
  
• A Surgeon's View on the Pathogenesis of Atherosclerosis. Circulation 2017; 135:205
  Haverich A.
  
• Acute myeloid leukemia derived from lympho-myeloid clonal hematopoiesis. Leukemia 2017; 31:1286
  Thol F., Klesse S., Köhler L., Gabdoulline R., Kloos A., Liebich A., Wichmann M., Chaturvedi A., Fabisch J., Gaidzik V.I., Paschka P., Bullinger L., Bug G., Serve H., Göhring G., Schlegelberger B., Lübbert M., Kirchner H., Wattad M., Kraemer D., Hertenstein B., Heil G., Fiedler W., Krauter J., Schlenk R.F., Döhner K., Döhner H., Ganser A., Heuser M.
  
• Autophagy determines efficiency of liver-directed gene therapy with adeno-associated viral vectors. Hepatology 2017; 66:252
  Hösel M., Huber A., et int, Büning H.
  
• Autophagy determines efficiency of liver-directed gene therapy with adenoassociated viral vectors. Hepatology 2017; 66:252
  Hösel M., Huber A., Bohlen S., Lucifora J., Ronzitti G., Puzzo F., Boisgerault F., Hacker U.T., Kwanten W.J., Klöting N., Blüher M., Gluschko A., Schramm M., Utermöhlen O., Bloch W., Mingozzi F., Krut O., Büning H.
  
• Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia. Nat Commun 2017; 8:952
  Krishnasamy K., Limbourg A., et int, Falk C. S., et int, Bauersachs J., et int, Limbourg F. P.
  
• Bromocriptine for the treatment of peripartum cardiomyopathy: a multicentre randomized study. Eur Heart J 2017; 38:2671
  Hilfiker-Kleiner D., Haghikia A., et int, Vogel-Claussen J., et int, Bauersachs J.
  
• Bromocriptine for the treatment of peripartum cardiomyopathy: a multicentre randomized study. Eur Heart J 2017; 38:2671
  Hilfiker-Kleiner D., Haghikia A., Berliner D., Vogel-Claussen J., Schwab J., Franke A., Schwarzkopf M., Ehlermann P., Pfister R., Michels G., Westenfeld R., Stangl V., Kindermann I., Kühl U., Angermann C.E., Schlitt A., Fischer D., Podewski E., Böhm M., Sliwa K., Bauersachs J.
  
• Controlled re-activation of epigenetically silenced Tet promoter-driven transgene expression by targeted demethylation. Nucleic Acids Res 2017; 45:e147
  Gödecke N., Zha L., et int, Hauser H., Wirth D.
  
• Development of Laser-Structured Liquid-Infused Titanium with Strong Biofilm-Repellent Properties. ACS Appl Mater Interfaces 2017; 9:9359
  Doll K., Fadeeva E., et int, Heisterkamp A., Chichkov B. N., Stiesch M., Stumpp N. S.
  
• Development of laser-structured liquid-infused titanium with strong biofilm-repellent properties. ACS Appl Mater Interfaces 2017; 9:9359
  Doll K., Fadeeva E., Schaeske J., Ehmke T., Winkel A., Heisterkamp A., Chichkov B.N., Stiesch M., Stumpp N.S.
  
• Discovery and Total Synthesis of Natural Cystobactamid Derivatives with Superior Activity against Gram-Negative Pathogens. Angew Chem Int Ed Engl 2017; 56:12760
  Hüttel S., Testolin G., et int, Kirschning A., Müller R.
  
• EBIO Does Not Induce Cardiomyogenesis in Human Pluripotent Stem Cells but Modulates Cardiac Subtype Enrichment by Lineage-Selective Survival. Stem Cell Reports 2017
  Jara-Avaca M., Kempf H., et int, Dräger G., Kirschning A., Martin U. , Zweigerdt R.
  
• EMC10 (Endoplasmic Reticulum Membrane Protein Complex Subunit 10) Is a Bone Marrow-Derived Angiogenic Growth Factor Promoting Tissue Repair After Myocardial Infarction. Circulation 2017; 136:1809
  Reboll M. R., Korf-Klingebiel M., et int, Gruh I., et int, Bauersachs J., et int, Wollert K. C.
  
• EMC10 (endoplasmic reticulum membrane protein complex subunit 10) is a bone marrow-derived angiogenic growth factor promoting tissue repair after myocardial infarction. Circulation 2017; 136:1809
  Reboll M.R., Korf-Klingebiel M., Klede S., Polten F., Brinkmann E., Reimann I., Schönfeld H.J., Bobadilla M., Faix J., Kensah G., Gruh I., Klintschar M., Gaestel M., Niessen H.W., Pich A., Bauersachs J., Gogos J.A., Wang Y., Wollert K.C.
  
• Growth Differentiation Factor 15 as a Biomarker in Cardiovascular Disease. Clin Chem 2017; 63:140
  Wollert K. C., Kempf T., Wallentin L.
  
• Hematopoietic stem cell gene therapy for IFNgammaR1 deficiency protects mice from mycobacterial infections. Blood 2017
  Hetzel M., Mucci A., Blank P., Nguyen A.H.H., Schiller J., Halle O., Kühnel M.P., Billig S., Meineke R., Brand D., Herder V., Baumgartner W., Bange F.C., Goethe R., Jonigk D., Förster R., Gentner B., Casanova J.L., Bustamante J., Schambach A., Kalinke U., Lachmann N.
  
• Human gammadelta T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection. Nat Immunol 2017; 18:393
  Ravens S., Schultze-Florey C., et int, Heuser M., et int, Ganser A., Förster R., et int, Prinz I.
  
• Inhibition of the Cardiac Fibroblast-Enriched lncRNA Meg3 Prevents Cardiac Fibrosis and Diastolic Dysfunction. Circ Res 2017; 121:575
  Piccoli M. T., Gupta S. K., et int, Thum T.
  
• Intracoronary autologous bone marrow cell transfer after myocardial infarction: the BOOST-2 randomised placebo-controlled clinical trial. Eur Heart J 2017; 38:2936
  Wollert K. C., Meyer G. P., et int, Ganser A., et int, Bauersachs J.
  
• Intracoronary autologous bone marrow cell transfer after myocardial infarction: the BOOST-2 randomised placebo-controlled clinical trial. Eur Heart J 2017; 38:2936
  Wollert K.C., Meyer G.P., Müller-Ehmsen J., Tschöpe C., Bonarjee V., Larsen A.I., May A.E., Empen K., Chorianopoulos E., Tebbe U., Waltenberger J., Mahrholdt H., Ritter B., Pirr J., Fischer D., Korf-Klingebiel M., Arseniev L., Heuft H.G., Brinchmann J.E., Messinger D., Hertenstein B., Ganser A., Katus H.A., Felix S.B., Gawaz M.P., Dickstein K., Schultheiss H.P., Ladage D., Greulich S., Bauersachs J.
  
• Low STAT3 expression sensitizes to toxic effects of beta-adrenergic receptor stimulation in peripartum cardiomyopathy. Eur Heart J 2017; 38:349
  Stapel B., Kohlhaas M., et int, Thackeray J. T., et int, Bengel F. M., et int, Bauersachs J., et int, Hilfiker-Kleiner D.
  
• Outcome of subsequent pregnancies in patients with a history of peripartum cardiomyopathy. Eur J Heart Fail 2017; 19:1723
  Hilfiker-Kleiner D., Haghikia A., et int, Bauersachs J. , Sliwa K.
  
• Quaking Inhibits Doxorubicin-Mediated Cardiotoxicity Through Regulation of Cardiac Circular RNA Expression. Circ Res 2017
  Gupta S. K., Garg A., Bär C., et int, Thum T.
  
• Simultaneous dual-isotope solid-state detector SPECT for improved tracking of white blood cells in suspected endocarditis. Eur Heart J 2017; 38:436
  Caobelli F., Wollenweber T., et int, Thackeray J. T., Bauersachs J., Haverich A., Bengel F. M.
  
• The chemokine receptor CX3CR1 coordinates monocyte recruitment and endothelial regeneration after arterial injury. EMBO Mol Med 2017
  Getzin T., Krishnasamy K., et int, Bauersachs J., et int, Limbourg F. P.
  
• The non-coding RNA landscape of human hematopoiesis and leukemia. Nat Commun 2017; 8:218
  Schwarzer A., Emmrich S., Schmidt F., Beck D., Ng M., Reimer C., Adams F.F., Grasedieck S., Witte D., Kabler S., Wong J.W.H., Shah A., Huang Y., Jammal R., Maroz A., Jongen-Lavrencic M., Schambach A., Kuchenbauer F., Pimanda J.E., Reinhardt D., Heckl D., Klusmann J.H.
  
• The transcription factor GATA4 promotes myocardial regeneration in neonatal mice. EMBO Mol Med 2017; 9:265
  Mohammadi M. M., Kattih B., et int, Kispert A., Wollert K. C., Bauersachs J., Heineke J.
  
• A large shRNA library approach identifies lncRNA Ntep as an essential regulator of cell proliferation. Cell Death Differ 2018; 25:307
  Beermann J., Kirste D., et int, Bär C., Thum T.
  
• Gauging cardiac repair and regeneration with new molecular probes. J Nucl Med 2018
  Thackeray J. T., Bengel F. M.
  
• Myocardial inflammation predicts remodeling and neuroinflammation after myocardial infarction. J Am Coll Cardiol 2018; 71:263
  Thackeray J.T., Hupe H.C., Wang Y., Bankstahl J.P., Berding G., Ross T.L., Bauersachs J., Wollert K.C., Bengel F.M.
  
• Myocardial Inflammation Predicts Remodeling and Neuroinflammation After Myocardial Infarction. J Am Coll of Cardiol 2018; 71:263
  Thackeray J. T., Hupe H. C., et int, Bauersachs J., Wollert K. C., Bengel F. M.
  
• RNA interference efficiently targets human leukemia driven by a fusion oncogene in vivo. Leukemia 2018; 32:224
  Jyotsana N., Sharma A., et int, Sajti L., et int, Eder M., et int, Ganser A., et int, Heuser M.
  
• Telemonitoring-supported exercise training, metabolic syndrome severity, and work ability in company employees: a randomised controlled trial; Lancet Public Health. 2019 Jul;4(7):e343-e352
  Haufe S, Kerling A, Protte G, Bayerle P, Stenner HT, Rolff S, Sundermeier T, Kück M, Ensslen R, Nachbar L, Lauenstein D, Böthig D, Bara C, Hanke AA, Terkamp C, Stiesch M, Hilfiker-Kleiner D, Haverich A, Tegtbur U