Multiscale models for carrier-assisted drug transport through skin
(B04)
Subject Area
Statistical Physics, Nonlinear Dynamics, Complex Systems, Soft and Fluid Matter, Biological Physics
Term
from 2013 to 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 234930468
Theoretical investigations on the mechanisms of nanocarrier-based drug transport through skin are pursued, employing a combination of atomistic simulations and stochastic modeling approaches. Multicomponent diffusion models for nanocarrier-assisted drug penetration into skin will be developed. Based on the new methodology developed in the first funding period to extract diffusivity profiles of molecules in lipid membranes from atomistic simulations, the diffusivities of a whole set of drugs in lipid membranes of different composition will be determined. Ultimately, these parameters will be incorporated into a bottom-up model for the transport of drug molecules through the stratum corneum.
DFG Programme
Collaborative Research Centres
