Aptamer Technologies (P01)

• Subject Area: Medicine
• Term: from 2013 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 227953431

This project will generate, characterize and provide aptamers that will be used in multiple projects for in vitro, cellular and in vivo applications. Aptamers have emerged as an alternative compound class providing high affinity binding and inhibition of biomolecules. The platform has successfully identified, characterized and applied aptamers and provided them to various groups within the CRC. The platform we will continue to provide individual subprojects with the required aptamers, fully characterized in terms of affinity and specificity. In addition, and in combination with the platform P02 'Recombinant adeno-associated- and lentiviral technologies’, we will construct and characterize recombinant viruses for the expression of aptamers in neurons and glia, which will make them also suitable for in vivo studies.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1089: Synaptic Micronetworks in Health and Disease
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Heads: Professor Dr. Michael Famulok, until 6/2017; Professor Dr. Ulrich Benjamin Kaupp, until 6/2017; Professor Dr. Günter Mayer