Modulation of IL-10- and/or STAT3-mediated tumor-associated tolerance-mechanisms with the help of functionalized nanoparticles (B06)

• Subject Area: Dermatology
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213555243

STAT3-mediated tumor-associated processes will be modulated by use of STAT3 inhibitor loaded function-alized nanocapsules. We will analyse the impact on tolerogenic DC and myeloid cells and, in particular, on T cells (regulatory FOXP3+, cytotoxic CD8+ T cells), thereby taking advantage of the established method of IL-2 functionalized nanocapsules for T cell targeting. Further studies will unravel the therapeutical effect of our nanocapsule-based systems (+/- immunotherapies) in murine and humanized [MISTRG] models of malignant melanoma in vivo.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1066: Nano-Dimensional Polymer Therapeutics for Tumour Therapy
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professorin Dr. Katharina Landfester; Professorin Dr. Kerstin Steinbrink