Therapy of primary and secondary liver tumors by addressing tolerance-inducing M2 macrophages using immunomodulating nanoparticles (B03)

• Subject Area: Hematology, Oncology
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213555243

M2-type cancer promoting macrophages in the liver cancer microenvironment will be repolarized to cancer suppressing M1-type macrophages using block copolymer-based cationic nanogels. The nanoparticles will be loaded with small molecular drugs, siRNA or antisense oligonucleotides. Targeted delivery and thus a more effective repolarization of M2-macrophages will be further improved by derivatisation of the nanopar-ticles with CD206-binding peptides or nanobodies. For in vivo efficacy testing we have established 3 syn-genic mouse models of hepatocellular carcinoma.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1066: Nano-Dimensional Polymer Therapeutics for Tumour Therapy
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professor Dr. Lutz Nuhn; Professor Dr. Detlef Schuppan; Privatdozentin Dr. Andrea Renate Tüttenberg, until 6/2021; Professor Dr. Rudolf Zentel, until 6/2021