Liposomes and polymersomes with multifunctional endgroups: targeting and controlled release (A07)

• Subject Area: Biological and Biomimetic Chemistry
• Term: from 2013 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213555243

Within this project the processing and loading (formulation) of polymersomes and liposomes as carriers for peptides, RNA and/or low molar mass pharmacons will be studied. It is thereby the speciality of these polymersomes that they can be coated with hyperbranched PEG and decorated with targeting structures. To modify the release as recondition for biomedical activity the stability of the basic polymersomal structure will be modified to allow stabilization (e.g. crosslinking) or destabilization by pH dependent degradation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1066: Nano-Dimensional Polymer Therapeutics for Tumour Therapy
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professor Dr. Holger Frey; Professor Dr. Mark Helm; Professor Dr. Rudolf Zentel