Inhibition of ether-phosphatidylserine synthesis and signaling for tumor therapy (B06)

The project asks if acute pharmacological or genetic inhibition of phosphatidylserine synthase 1 suppresses tumor development murine and human models, also in combination with current therapy approaches. Moreover, mechanisms how ether phosphatidylserine (ePS) affects PS externalization will be investigated, and a potential signaling function of lyso-ePS in tumor and immune cells will be tested.

DFG Programme Collaborative Research Centres

Subproject of SFB 1039:  Signalling by Fatty Acid Derivatives and Sphingolipids in Health and Disease

Applicant Institution Goethe-Universität Frankfurt am Main

Project Head Professor Dr. Andreas Weigert