Sphingolipid- and Matrix –mediated Signalling pathways in chronic inflamation and fibrosis of the kidney (B02)

This project aims at investigating the therapeutic potential of specific inhibitors of S1PR5, the Spns2 transporter and of a novel S1PR1 G protein-biased agonist for an antifibrotic effect in kidney injury models. Mechanistically, the decreased degradation of antifibrotic Smad7 due to sphingosin-mediated reduction of ubiquitin ligases will be elucidated. Further experiments will particularly address the impact of specific chain-lengths of S1P and the crosstalk of S1P and the proteoglycan biglycan in renal inflammation, resolution and fibrosis.

DFG Programme Collaborative Research Centres

Subproject of SFB 1039:  Signalling by Fatty Acid Derivatives and Sphingolipids in Health and Disease

Applicant Institution Goethe-Universität Frankfurt am Main

Project Heads Professor Dr. Josef M. Pfeilschifter; Professorin Dr. Liliana Schaefer