INFLUENCE OF A LOCAL INFLAMMATION ON LIPIDSYNTHESIS AND -SIGNALING IN MEGAKARYOCYTES AND THROMBOCYTES (A08)

The project aims to study how a local peripheral inflammation influences lipidsynthesis and -signaling in megakaryocytes and thrombocytes. mRNA sequencing and proteome analyses showed that a local inflammation upregulates the expression of proinflammatory proteins in megakaryocytes and thrombocytes. The role of observed changes in the lipidome will be investigated in both cell types with focus on aggregation of thrombocytes, vascular permeability, and thrombocyte-associated macrophages. Finally, the data generated in mice will be studied for their significance for chronic inflammatory skin diseases using biopsies and blood samples from patients.

DFG Programme Collaborative Research Centres

Subproject of SFB 1039:  Signalling by Fatty Acid Derivatives and Sphingolipids in Health and Disease

Applicant Institution Goethe-Universität Frankfurt am Main

Project Heads Professor Dr. Gerd Geißlinger; Professor Dr. Klaus Scholich